tag:blogger.com,1999:blog-2238276534410758837.post7640610895617074866..comments2023-08-29T08:17:53.986-07:00Comments on Multiple Sclerosis--the vascular connection: Vascular factors affect MS disease progressionJoanhttp://www.blogger.com/profile/09439558270245339942noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-2238276534410758837.post-50463749026293586132018-01-22T10:11:01.308-08:002018-01-22T10:11:01.308-08:00Yes--you've found an important paper! I blogg...Yes--you've found an important paper! I blogged about this three years ago---http://ccsviinms.blogspot.com/2015/02/putting-pieces-together.html<br /><br />"Dr. Zamboni has noted that there is a derangement of the endothelial cell layer in the jugular veins and valves in people with CCSVI/MS. This loss of endothelial cells could well be causing the decrease in cerebrovascular reactivity seen in people with MS. And it is caused by CCSVI.<br />http://phl.sagepub.com/content/early/2014/06/27/0268355514541980.abstract"<br /><br /><br />Having discussed this with Dr. John Cooke, who is a leading endothelial cell researcher now working on creating new ECs using fibroblasts, there is a possibility of regenerating ECs. I created the Endothelial Health Program, based on Dr. Cooke's cardiovascular research, to repair and regenerate these cells. EC proginators, which come from bone marrow, can be regenerated with lifestyle---including exercise and a Mediterranean diet. But they also need shear stress to survive---and if jugular valves are frozen, or cannot move--there is not enough blood flow for regeneration, and slowed circulation and EC death occurs. This is why CCSVI needs to be treated. Joanhttps://www.blogger.com/profile/09439558270245339942noreply@blogger.comtag:blogger.com,1999:blog-2238276534410758837.post-64818519035251929622018-01-22T08:06:51.171-08:002018-01-22T08:06:51.171-08:00Hi Joan!
Great post and great news as usual.
I jus...Hi Joan!<br />Great post and great news as usual.<br />I just stumbled upon this article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574083/<br />I was quite surprised to know that "no endothelial cells were found in the defective cusps, and the surface of the structure is covered by a fibro-reticular lamina." of the internal jugular veins of pwMS.<br />Given all your research, is there anything we can do to repair this? Is the endothelial program any effective given already the absence of endothelial cells?<br />I look forward to your reply!<br />Thanks as usual!<br />Ricardoriclealhttps://www.blogger.com/profile/05198753753628311378noreply@blogger.comtag:blogger.com,1999:blog-2238276534410758837.post-50047223952299677162018-01-21T23:58:15.242-08:002018-01-21T23:58:15.242-08:00Le Interazioni Tra INFIAMMAZIONI e COAGULAZIONI
....Le Interazioni Tra INFIAMMAZIONI e COAGULAZIONI <br />.Formato : Estratto Br J Haematol. 2005 nov; 131 (4): 417-30.<br /><br />L'Infiammazione AVVIA la Coagulazione, diminuisce l'attività dei meccanismi anticoagulanti naturali e Danneggia il Sistema Fibrinolitico.<br /><br />Le Citochine infiammatorie sono i principali mediatori coinvolti nell'attivazione della coagulazione.<br /><br />Gli Anti-Coagulanti Naturali funzionano per smorzare l'innalzamento dei livelli di citochine.<br /><br />Inoltre, i componenti delle cascate anticoagulanti naturali, come la Trombomodulina, riducono al minimo la Disfunzione delle Cellule ENDOTELIALI rendendo le cellule meno reattive ai mediatori dell'infiammazione, facilitano la neutralizzazione di alcuni mediatori dell'infiammazione e riducono la perdita della funzione di barriera endoteliale.<br /><br />QUINDI, la Downregulation dei percorsi anticoagulanti NON SOLO promuove la Trombosi, MA Amplifica anche il Processo Infiammatorio.<br /><br />QUANDO le interazioni di infiammazione e coagulazione travolgono i sistemi naturali di difesa, si Verificano Eventi Catastrofici,<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/16281932/<br /><br />PMID: 16281932 DOI: 10.1111 / j.1365-2141.2005.05753.x<br />[Indicizzato per MEDLINE]ruggierifphttps://www.blogger.com/profile/17078069090189913033noreply@blogger.comtag:blogger.com,1999:blog-2238276534410758837.post-74494172594310631172018-01-21T17:31:33.527-08:002018-01-21T17:31:33.527-08:00Thank you always Joan for speaking truths from m...Thank you always Joan for speaking truths from me here in the UK always speak out .Lynnie Healhttps://www.blogger.com/profile/13932647784833428210noreply@blogger.com