Welcome! This blog contains research & information on lifestyle, nutrition and health for those with MS, as well as continuing information on the understanding of the endothelium and heart-brain connection. This blog is informative only--all medical decisions should be discussed with your own physicians.

The posts are searchable---simply type in your topic of interest in the search box at the top left.

Almost all of MS research is initiated and funded by pharmaceutical companies. This maintains the EAE mouse model and the auto-immune paradigm of MS, and continues the 20 billion dollar a year MS treatment industry. But as we learn more about slowed blood flow, gray matter atrophy, and environmental links to MS progression and disability--all things the current drugs do not address--we're discovering more about how to help those with MS.

To learn how this journey began, read my first post from August, 2009. Be well! Joan

Friday, May 13, 2011

Jugular venous reflux could influence cerebral blood flow and neurological disease

May 13, 2011 at 8:18am

Anyone who has been following this page for awhile knows about the research in Taiwan by Dr. Chung and his associates into jugular valve insufficiency and transient global amnesia.  I wrote to Dr. Chung in '09 and sent him all of Dr. Zamboni's research, noting that I thought he would find some interesting and complimentary discoveries to his own research on the jugular veins.

Dr. Chung and his associates are different in their studies, in that they employ valsalva manuever (exerting pressure against a closed airway-- which happens during straining, sneezing, breath-holding, etc) in order to create jugular reflux, and as we all know, Dr. Zamboni finds reflux in those with CCSVI during normal breathing.

It appears Dr. Chung's team is now looking at CCSVI.  We can only hope they bring further understanding into how jugular venous reflux affects cerebral blood flow and perfusion---
 Acta Neurol Taiwan. 2011 Mar;20(1):1-3.
Jugular venous reflux and neurological disorders.
Hsu HY.
Department of Neurology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan 

  • Abstract
    Usually, disturbance of arterial blood supply and circulation of cerebrospinal fluid are considered more clinically relevant, though accumulating data suggest that cerebral venous insufficiency does have important pathophysiological consequences in various neurological diseases(1-5). Hindrance of principal and collateral cerebral venous outflow will cause elevation of venous pressure, insufficiency of cerebral blood flow (CBF), increase of intracranial pressure, and eventually lead to parenchymal abnormalities. Disorders involving cerebral venous circulation, such as cerebral sinus thrombosis, dural arteriovenous fistula, and surgical sacrifice of the cerebral veins, may lead to serious complications. However, most physicians do not assign practical importance to cerebral venous circulation.

  •  Internal jugular vein (IJV) is a main extracranial route for cerebral venous drainage. The jugular venous valves, which are located near the junction with the innominant vein, prevent the transmission of thoracic pressure and the reflux of venous blood into the cerebral circulation. Jugular valve insufficiency could result in retrograde jugular venous flow and back transmission of central venous pressure. 
  • Previous studies have found significant associations between jugular venous reflux (JVR) and neurological disorders including transient global amnesia(1), transient monocular blindness(2), multiple sclerosis(3), exertional headache(4), and idiopathic intracranial hypertension(6). Investigators from Taiwan contributed a lot to current understanding in the cerebral venous circulation(1,2,7-9). However, there are some conceptual and technical limitations that challenge the relationship between JVR and clinical symptoms. Moreover, the association between JVR and neurological diseases can not be translate directly into a causal relationship. 
  • In this issue, Chung et al. demonstrate that JVR influences cerebral blood flow while performing a Valsalva manerver in their study(10). This study gives direct evidence that supports the effect of JVR on CBF. This finding provides supplementary information to their previous works concerning the relationship between JVR and neurological disorders, and also raises some questions. 
  • The main venous drainage routes vary with aging and are different among individuals(11,12). The extent and distribution of reduced cerebral perfusion resulting from right and left JVR could be different. The right JVR had a greater influence on CBF compared with left JVR in current study(10). In contrast, JVR occurred more frequently on left side in their previous study(1). The inconsistent findings may result from variations in the anatomic configuration of cerebral venous system, study population, and the capacity of collateral circles for drainage. Besides, the IJV may collapse and blood is shunted to an alternative venous pathway in standing position in which most neurological symptoms occurs(13).
  •  The influence of JVR on CBF in standing position has not been well evaluated. Some authors suggested a postural element was involved in the pathophysiology of cerebral venous insufficiency(14). Factors that determining the greater influence of JVR on CBF need further studies. Methods for diagnosing JVR vary in different studies. There is no consensus in quantification and diagnosis of cerebral venous insufficiency currently. 
  • Magnetic resonance venography (MRV) is able to demonstrate the extent of intracranial venous reflux and related parenchymal lesion(s). However, recent study showed that MRV had limited value for diagnosis of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis(15).
  •  Noninvasive sonography has good sensitivity and specificity in detecting cerebral venous insufficiency(3,15,16). In addition, sonography has the advantage in evaluation of dynamic flow changes during various physiological challenges, notably Valsalva maneuver. Sonography is a good tool for the detection of cerebral venous insufficiency and JVR in experienced hands. The use of ultrasound contrast and respiratory maneuvers could be helpful in diagnosing cerebral venous insufficiency, but not essential. 
  • Selective venography helps to determine the location of venous stenosis/ occlusion and to measure the venous pressure directly. Furthermore, endovascular treatment has been reported effective in relieving intracranial hypertension and improving neurological function in some multiple sclerosis patients(17). Still, extrapolating the benefit of intravenous interventions should be cautious because there is no randomized trial yet(18,19). 
  • Current understanding of cerebral venous disorders is imperfect. Clinical evaluation of cerebral venous circulation is somewhat difficult because variation in the anatomic configuration of cerebral venous system is a rule. Although the pathogenetic role of JVR needs more evidence to prove, cerebral venous insufficiency could be a neglected and treatable cause of some neurological disorders. Further studies may be needed to provide more insight into JVR and its potential relationship with neurological disorders.

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