Welcome! This blog contains research, information on lifestyle, nutrition, dietary supplements and health for those with MS, as well as continuing information on the understanding of CCSVI and cerebral hypoperfusion. This blog is informative only--all medical decisions should be discussed with your own physicians.

The posts are searchable---simply type in your topic of interest in the search box at the top left.

Almost all of MS research is initiated and funded by pharmaceutical companies. This maintains the EAE mouse model and the immune paradigm of MS, and continues the 15 billion dollar a year MS treatment industry. But as we learn more about slowed blood flow, gray matter atrophy, and environmental links to MS progression and disability--all things the current drugs do not address--we're discovering more about how to help those with MS.

To learn how this journey began, read my first post from August, 2009. Be well! Joan

Wednesday, March 14, 2012

Vascular Health and the Brain--the Eyes Have it.

March 14, 2012 at 4:16pm

“Vascular health has a direct effect on the brain, and you can see those developments when you look at the eye,” says Haan, from UCSF.

A new study shows the link between retinal health and the health of the brain.  
This link has already been made with OCT (optical coherence tomography) retinal scans in Multiple Sclerosis--

The health of easy-to-check blood vessels in the retina reflects the health of blood vessels deep inside the head, findings that raise the possibility of a simple eye exam catching early signs of brain trouble, scientists report in the March 27 Neurology. 

The findings add to the growing number of studies focusing on blood vessels that link eye and brain health. The Neurology study was conducted as part of the Women’s Health Initiative, which tracks the health of postmenopausal women. Over 10 years, researchers led by epidemiologist and biostatistician Mary Haan of the University of California, San Francisco looked for a link between eye disease and brain performance in 511 women who were at least 65 years old. 

In the study, participants had their pupils dilated as researchers took pictures of their retinas. After careful examinations, 39 women, or 7.6 percent of the total, were found to have diseased blood vessels in the retina, a condition called retinopathy in which the vessels can become swollen, leaky or grow abnormally. Usually, retinopathy is a symptom of diabetes or high blood pressure, two disorders that if left untreated are known to affect brain functioning.

Over the decade of testing, women with retinopathy scored about 10 to 15 percent lower on questionnaires that tested brain functions such as memory, verbal fluency and writing than did women without the eye disease. What’s more, MRI scans revealed that women with retinopathy had more blood vessel damage in their brains — and also more areas of damage to brain tissue, possibly from tiny strokes. 

Friday, March 9, 2012

Pregnancy, MS and changes to the veins

March 9, 2012 at 3:53pm

There's a new Australian study being picked up by the media on pregnancy and MS.

A study by the Murdoch Children’s Research Institute in Victoria, published today, found women with at least one child have about half the risk of early MS symptoms compared to women without children.  The risk of developing symptoms of the incurable disease appear to drop with each additional child.  For example, women with three children have a 75% lower risk of early MS symptoms compared to women without children.

Lead researcher Anne-Louise Ponsonby says although the study found only an association between pregnancy and a lower risk of MS symptoms - not a direct cause-and-effect link - it could help explain why the incidence of MS in women has increased in past few decades.

"Our research suggests that this may be due to mothers having children later in life and having fewer children than they've had in past years," Ms Ponsonby said in a statement.   The study, which involved 800 women, also found the benefits of pregnancy seemed to remain even after researchers accounted for other factors such as smoking, skin damage and sun exposure and certain susceptibility genes.  "In our study, the risk went down with each pregnancy and the benefit was permanent."


Naturally, there is lot of discussion on how the immune system is modulated while carrying a fetus...something the body sees as "other" and how this might affect MS.  And many people have mentioned hormones, especially estrogen.

But I wanted to discuss the vascular changes that happen while a woman is pregnant, because I never see this discussed, and I hope to encourage the ISNVD and other MS researchers to look into this correlation.

During pregnancy, a woman's blood volume increases by 50%.   This is to nourish the placenta and growing fetus, and also to compensate for blood loss during delivery.  If the blood vessels remained the same, with more blood volume, blood pressure would become dangerously high....so, the veins become more pliant, open and relaxed.  This is why many women develop varicose veins or hemorrhoids during preganancy.