Welcome! This blog contains research & information on lifestyle, nutrition and health for those with MS, as well as continuing information on the understanding of the endothelium and heart-brain connection. This blog is informative only--all medical decisions should be discussed with your own physicians.The posts are searchable---simply type in your topic of interest in the search box at the top left.Almost all of MS research is initiated and funded by pharmaceutical companies. This maintains the EAE mouse model and the auto-immune paradigm of MS, and continues the 20 billion dollar a year MS treatment industry. But as we learn more about slowed blood flow, gray matter atrophy, and environmental links to MS progression and disability--all things the current drugs do not address--we're discovering more about how to help those with MS.To learn how this journey began, read my first post from August, 2009. Be well! Joan
Thursday, February 28, 2013
Abstracts from 2013 ISNVD Conference
February 28, 2013 at 7:51am
The abstracts from the recent International Society for Neurovascular Disease conference are now available on line in a pdf format:
A brief rundown of some of the 63 pages on abstracts--
Dr. Niggemann presents research showing how positional MRV can be used to show cerebral blood flow in supine and upright positions. This is a huge step forward.
Dr. Raju presents research on the efficacy of illiac vein stenting, since this has been done for a longer period of time in those with illiac vein stenosis. Research shows that this procedure is most successful in those who are earlier in the disease process, and who have less damage to the organ.
Dr. Zivadinov presented on CCSVI research at ECTRIMS 2012, looking at modalities for detection and CCSVI in pediatric MS and other neurological diseases.
Researchers from the MRI institute in Amsterdam presented on cerebral venous return and other chronic neurological conditions.
Dr. Mancini looked at cerebral circulation time in people with MS using contrast enhanced ultrasound, showing that pwMS have much slower cerebral circulation than healthy controls.
Euromedic group of Poland reported on endovascular treatment of CCSVI using cutting balloons, as opposed to stenting or simple ballooning. They found good success.
A group from Naples reported on CCSVI venoplasty in 144 cases, reporting sustained and good results in 55% of those treated.
BNAC reported on parts of their Premise study, including the use of IVUS rather than just venography, and found IVUS was superior in detecting extracranial venous abnormalities in pwMS. They also reported on their CSF study, which showed an improvement in CSF flow a year after venoplasty.
A group from Rome reported on 3 month and 1 year improvements in 577 patients treated with venoplasty for CCSVI, as seen on doppler ultrasound. 511 patients were scanned at three months and 91% showed maintained venous outflow. 385 patients were scanned at one year and 80% showed no CCSVI recurrence.
Another group from Rome reported on 1202 patients treated for CCSVI at two separate centers. This study reported on adverse effects and complications, noting that CCSVI treatment was safe and effective--and that experience of the centers is very important in outcome of treatment.
Dr. Beggs and Dr. Zamboni reported on the use of the cervical plethysmography collar, showing the pwCCSVI had significantly different blood flow than normals. The rate of hydraulic resistance was 63.5% greater in people with CCSVI...when people with CCSVI sat up, their blood flow back to the heart was much slower than normal.
There was also an interesting paper from Dr. Beggs and BNAC on how CCSVI affects normals...showing slowed cerebrospinal fluid and hypertension in the dural sinuses.
Dr. Steven Alexander and Dr. Minagar collaborated with BNAC, looking at plasma from people with MS, finding microparticles that show endothelial dysfunction, and imply vascular stress and injury in MS.
Dr. Haake and Drs. Hewitt and Arata reported on white and gray matter hemodynamic changes in people with clinically isolated syndrome and MS, and also reported on the differences in digital subtraction angiography and contrast enhanced MRI in detecting CCSVI.
For further and much more in-depth information, click on the pdf linked above and read through the research. Happy reading!