Welcome! This blog contains research & information on lifestyle, nutrition and health for those with MS, as well as continuing information on the understanding of the endothelium and heart-brain connection. This blog is informative only--all medical decisions should be discussed with your own physicians.

The posts are searchable---simply type in your topic of interest in the search box at the top left.

Almost all of MS research is initiated and funded by pharmaceutical companies. This maintains the EAE mouse model and the auto-immune paradigm of MS, and continues the 20 billion dollar a year MS treatment industry. But as we learn more about slowed blood flow, gray matter atrophy, and environmental links to MS progression and disability--all things the current drugs do not address--we're discovering more about how to help those with MS.

To learn how this journey began, read my first post from August, 2009. Be well! Joan

Wednesday, March 27, 2013

BNAC research : A Tale of Two Studies


March 27, 2013 at 2:43pm

There have been two venoplasty studies undertaken by the University of Buffalo and recently released/publicized.  I thought it might be good to compare them, side by side.  Because the conclusions and results are worlds apart, and there needs to be an explanation.

Dr. Robert Zivadinov is the lead investigator in both studies.

PREMiSe Study Phase #1  Cine/CSF Study  
Published in the Journal of Vascular Radiology March 2013
No publicity  
Discussed at International Society for Neurovascular Disease Conference

PREMiSe Study Phase #2
Poster/Publicity at American Academy of Neurology  March 2013
Press conferences, videos, lots of news coverage all over the world.

Both are Venoplasty studies in mainly RRMS patients.  

PREMiSe study phase 1--Dr. Robert Galleotti, treating IR 
has worked with Dr. Zamboni for many years, has treated hundreds of CCSVI patients
an expert in venoplasty for CCSVI.  Venous drainage is improved >75%


"Improved venous parenchyma drainage"  Lower number of lesions on MRI for treated patients, less relapses.  
More studies are warranted!  PTA is good for the brain.


PREMiSe study phase 2-- Dr. Adnan Siddiqui, treating IR, relatively new to CCSVI venoplasty
Venous drainage is NOT improved to marker of >75%.  In fact, it is only improved to 50%!  (meaning treatment was a failure!!!)
 Headlines read, Liberation Therapy may make MS worse!
Nine patients treated, showed 19 new lesions on MRI.  PTA is bad.


 "more sizable changes in venous outflow [were] associated with increased disease activity primarily noted on MRI,"  Dr. Zivadinov and his colleagues concluded.


How are we to know what to believe? 
Is venoplasty helpful or harmful?  Is this about experience in the treating IR?  
Is this about how research is framed for the different audiences of vascular vs. neurological conferences?  

 If phase 2 of PREMiSe did not reach a restoration of <75% venous flow, as it was supposed to....is this trial a failure?  

Because one study shows the venoplasty for CCSVI reduces lesions, relapses and improves CSF and venous drainage when flow is restored to <75%.

while the other study shows the exact opposite.
Which is the truth?

Does anyone want to answer this?
Joan

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2 comments:

  1. UnknownJuly 1, 2014 at 3:00 PM

    yeah, they get mixed up in their own lies..and why the univ of buffalo and not harvard? i mean why so little interest? and how can they ignore the thousands of people for whom the ccsvi treatment worked?

    ReplyDelete
  2. Lynnie HealJuly 26, 2014 at 11:42 AM

    Thankyou for doing this with truths

    ReplyDelete

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