From a press release from the Perelmen School of Medicine at the University of Pennsylvania's Kahn Lab-- on research published in The Journal of Clinical Investigation's August issue:
Flow means "go" for proper lymph system development
PHILADELPHIA--The lymphatic system provides a slow flow of fluid from our organs and tissues into the bloodstream. It returns fluid and proteins that leak from blood vessels, provides passage for immune and inflammatory cells from the tissues to the blood, and hosts key niches for immune cells. How this system develops hasn't been well understood, but now researchers from the Perelman School of Medicine at the University of Pennsylvania have found from experiments in mice that the early flow of lymph fluid is a critical factor in the development of mature lymphatic vessels.
The project was prompted in part by recent studies of cultured lymphatic vessel endothelial cells that suggested that fluid forces could be an important factor in the maturation of lymphatic vessels. But there was no straightforward way to test this hypothesis in live animals.
If flow is essential for a healthy lymphatic cleansing system---which we now know is part of the brain as well as other organs---the lack of venous drainage for the brain and spine could have disaterous affects on immune cells and metabolite cleansing processes. And reflux and slowed flow of venous blood in the jugular veins--as noted in CCSVI--could be shutting down the lymphatic drainage system of the brain. Endothelial dysfunction, which has also been noted in MS, also plays a role in the cessation of lymphatic flow. Flowing fluids create shear stress, and are needed for healthy endothelial cells. It's a virtuous cycle.
Venous flow matters. Jugular flow matters. Lymphatic vessel flow matters. The basic science is being established.