New research from the University of Rochester, published today, reconfirms the importance of sleep for brain health.Their results, published in Science, show that during sleep a plumbing system called the glymphatic system may open, letting fluid flow rapidly through the brain. Dr. Nedergaard's lab recently discovered the glymphatic system helps control the flow of cerebrospinal fluid (CSF), a clear liquid surrounding the brain and spinal cord."It's as if Dr. Nedergaard and her colleagues have uncovered a network of hidden caves and these exciting results highlight the potential importance of the network in normal brain function," said Roderick Corriveau, Ph.D., a program director at NINDS.
A few years ago, I first wrote about REM sleep and brain oxygenation. After venoplasty and restoration of jugular, rather than collateral venous flow, my husband Jeff had a return of dreaming and restful sleep. Now that his jugular veins had been repaired, they were the major route of venous return for his brain while he slept, and the changes for him were immense and immediate. After coming home from his procedure at Stanford, he no longer had night time spasms or fits of apnea, when he would literally wake up, gasping for air. He now slept through the night, and woke refreshed. He could now recount his very vivid dreams to me. This was all new for him.
When I attended the first CCSVI conference in Bologna in 2009, I heard Dr. Salvi talk about the restoration of REM sleep and dreaming in Italian patients that had been treated for CCSVI. It was the first intimation that something vital was happening to Jeff's brain while he was in deep sleep. Here is my post on this topic, with research on oxygenation of the brain during sleep--
Earlier this year, a new study from the University of Wisconsin showed us why sleep is essential for remyelination of the brain and synthesis of oligodendrocyte precursor cells.
They found that during sleep, hundreds of transcripts that govern the synthesis of cells called oligodendrocyte precursor cells (OPCs) are up-regulated during sleep, while genes involved in cell death, cell stress response and cell differentiation are up-regulated during wake. An assay of living cells confirmed that OPC proliferation doubles during sleep, especially during rapid eye movement phase (
And today, a new study from the University of Rochester helps us understand the different functions the brain performs during sleep and wake, and why sleep is essential.
In findings that give fresh meaning to the old adage that a good night's sleep clears the mind, a new study shows that a recently discovered system that flushes waste from the brain is primarily active during sleep. This revelation could transform scientists' understanding of the biological purpose of sleep and point to new ways to treat neurological disorders.
Time for the BIG picture. When we lie down, our cerebral circulation changes. This is, due in large part, to the fact that gravity allows the jugular venous system to become the main outflow. The collateral venous system, which is activated when we are upright, gives way to the larger jugular veins. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665206/
I would submit to you that this is the future.
While many MS specialists continue to meet in lovely locales, eat fine food, have laughs and drinks and attend pharmaceutically financed presentations-- only to return home and bemoan the fact that there are still no treatments for progressive MS---
There is a group of researchers committed to understanding cerebral hemodynamics and the role of the venous system on brain health. Here's their scientific program.
Let's support them.
Make a donation to the ISNVD today. Click on the orange button on the top right hand corner of their page, and fund the future.