New research from the Washington University School of Medicine outlines how higher levels of the blood vessel receptor protein S1PR2 in women might be creating higher MS rates in women.
S1PR2 is a receptor which signals the endothelium (the cellular lining of our blood vessels). It tells the endothelium which cells and molecules can pass through into tissue. In the case of MS--this process affects the brain and spine. An overexpression of this receptor may be behind MS.
The research, conducted at Washington University School of Medicine in St. Louis and published in the Journal of Clinical Investigation, found higher levels of a blood vessel receptor protein called S1PR2 in both female mice and women who were vulnerable to MS. What's more, S1PR2 was even higher in the parts of the brains of the women and mice that MS usually affects.