New technologies are allowing researchers to view the MS brain at a cellular level, before formation of lesions. I wanted to share three of these new papers, all published in the last month.
Please note that the researchers are cellular biologists---they are looking at the MS brain on the most basic level, and they all see the vascular links to the disease. They are not studying MS to find out how immune modulating drugs work, they are trying to solve the mystery of what causes MS. And they are all seeing a connection to blood flow and the blood brain barrier.
When neurologists tell you CCSVI research is over, please point them to the continuing, confirming research which is further elucidating the vascular connection to MS.
If NASA can work directly with Dr. Paolo Zamboni, why won't neurologists?
NASA wants to understand why 20% of their astronauts are coming back to earth with neurological and visual issues, and how it's related to blood flow. So, they went to the expert.
Here are the brand new papers, all finding a link to MS and blood flow.
1. The Role of Angiogenesis in the Pathology of MS
Cell biologists from the University of Irvine have noted how the loss of endothelial tight junctions in the blood brain barrier contributes to inflammation and angiogenesis (the growth of new blood vessels) in the MS brain, and how this process is initiated by hypoxia. This low oxygen state and resultant angiogenesis occurs prior to formation of demyelinating lesions.
This cellular research is further defining the hypothesis of cellular biologist Dr. Bernhard Juurlink, made in the 1990s.
It also fits in with my hypothesis of MS as a disease of hypoperfusion/reperfusion injury.
2. In vitro study of the direct effect of extracellular hemoglobin on myelin components.
The cellular biologists from the University of Guelph are looking at how blood particles damage myelin. They are seeing microscopic deposits of hemoglobin in the MS brain, around the veins. This blood contains iron, which when deposited into delicate brain tissue, begins a process of oxidative stress.